Silicon-based nanochannel glucose sensor

Details Silicon-based nanochannel glucose sensor Silicon-based nanochannel glucose sensor

2008-02-12

arxiv.org/abs/0802.1721v1

Appl. Phys. Lett. 92, 013903 (2008)

Physics

Biological Physics

3 pages, 3 figures, two-column format. Related papers can be found at http://nano.bu.edu

Scientific paper

10.1063/1.2832648

Silicon nanochannel biological field effect transistors have been developed for glucose detection. The device is nanofabricated from a silicon-on-insulator wafer with a top-down approach and surface functionalized with glucose oxidase. The differential conductance of silicon nanowires, tuned with source-drain bias voltage, is demonstrated to be sensitive to the biocatalyzed oxidation of glucose. The glucose biosensor response is linear in the 0.5-8 mM concentration range with 3-5 min response time. This silicon nanochannel-based glucose biosensor technology offers the possibility of high density, high quality glucose biosensor integration with silicon-based circuitry.

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