Global organization of metabolic fluxes in the bacterium, Escherichia coli

Details Global organization of metabolic fluxes in the bacterium, Escherichia coli Global organization of metabolic fluxes in the bacterium, Escherichia coli

2004-02-28

arxiv.org/abs/q-bio/0403001v1

Nature 427, 839-843 (2004)

Biology

Quantitative Biology

Molecular Networks

15 pages 4 figures

Scientific paper

Cellular metabolism, the integrated interconversion of thousands of metabolic substrates through enzyme-catalyzed biochemical reactions, is the most investigated complex intercellular web of molecular interactions. While the topological organization of individual reactions into metabolic networks is increasingly well understood, the principles governing their global functional utilization under different growth conditions pose many open questions. We implement a flux balance analysis of the E. coli MG1655 metabolism, finding that the network utilization is highly uneven: while most metabolic reactions have small fluxes, the metabolism's activity is dominated by several reactions with very high fluxes. E. coli responds to changes in growth conditions by reorganizing the rates of selected fluxes predominantly within this high flux backbone. The identified behavior likely represents a universal feature of metabolic activity in all cells, with potential implications to metabolic engineering.

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