A mathematical model for the germinal center morphology and affinity maturation

Details A mathematical model for the germinal center morphology and affinity maturation A mathematical model for the germinal center morphology and affinity maturation

2002-03-07

arxiv.org/abs/physics/0203021v1

Physics

Biological Physics

64 pages, 12 figures, accepted for publication in J. Theor. Biol

Scientific paper

During germinal center reactions the appearance of two specific zones is observed: the dark and the light zone. Up to now, the origin and function of these zones are poorly understood. In the framework of a stochastic and discrete model several possible pathways of zone development during germinal center reactions are investigated. The importance of the zones in the germinal center for affinity maturation, i.e. the process of antibody optimization is discussed.

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