Stretching of proteins in a force-clamp

Details Stretching of proteins in a force-clamp Stretching of proteins in a force-clamp

2005-12-01

arxiv.org/abs/q-bio/0512004v1

Biology

Quantitative Biology

Biomolecules

14 pages, 6 figures; submitted to J. Phys. Cond. Matt

Scientific paper

Mechanically induced protein unfolding in the force-clamp apparatus is shown, in a coarse-grained model of ubiquitin, to have lognormal statistics above a treshold force and exponential below it. Correspondingly, the mean unfolding time is slowly varying and exponentially decreases as a function of the force. The time dependencies of the end-to-end distances are also distinct. The time sequence of unfolding events weakly depends on force and much of it resembles that for stretching at constant speed. A more complicated time dependence arises for integrin.

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