Biology – Quantitative Biology – Molecular Networks
Scientific paper
2009-05-27
Biology
Quantitative Biology
Molecular Networks
32 pages, 6 figures
Scientific paper
Tumor Necrosis Factor alpha (TNF) initiates a complex series of biochemical events in the cell upon binding to its type R1 receptor (TNF-R1). Recent experimental work has unravelled the molecular regulation of the recruitment of initial signaling complexes that lead either to cell survival or death. Survival signals are activated by direct binding of TNF to TNF-R1 at the cell membrane whereas apoptotic signals by endocytosed TNF/TNF-R1 complexes. Here we investigate these aspects by developing a quantitative mathematical model of TNF binding, internalization and intracellular signaling. Model outputs compare favorably with experimental data and allow to compute TNF-mediated cytotoxicity as observed in different cell systems. We extensively study the space of parameters to show that the model is structurally stable and robust over a broad range of parameter values. Thus, our model is suitable for implementation in multi-scale simulation programs that are presently under development to study the behavior of large tumor cell populations.
Chignola Roberto
Fabbro Alessio Del
Farina Marcello
Milotti Edoardo
No associations
LandOfFree
Balance between cell survival and death: a minimal quantitative model of tumor necrosis factor alpha cytotoxicity does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Balance between cell survival and death: a minimal quantitative model of tumor necrosis factor alpha cytotoxicity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Balance between cell survival and death: a minimal quantitative model of tumor necrosis factor alpha cytotoxicity will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-527587