Biology – Quantitative Biology – Molecular Networks
Scientific paper
2008-10-10
physicalbiology 6, 046005-11 (2009)
Biology
Quantitative Biology
Molecular Networks
10 Figures, 3 Tables, 16 pages, submitted to physicalbiology
Scientific paper
10.1088/1478-3975/6/4/046005
Rigidity analysis using the "pebble game" can usefully be applied to protein crystal structures to obtain information on protein folding, assembly and the structure-function relationship. However, previous work using this technique has not made clear how sensitive rigidity analysis is to small structural variations. We present a comparative study in which rigidity analysis is applied to multiple structures, derived from different organisms and different conditions of crystallisation, for each of several different proteins. We find that rigidity analysis is best used as a comparative tool to highlight the effects of structural variation. Our use of multiple protein structures brings out a previously unnoticed peculiarity in the rigidity of trypsin.
Jimenez-Roldan Emilio J.
R{ö}mer Rudolf A.
Wells Stephen A.
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