Integrin activation - the importance of a positive feedback

Details Integrin activation - the importance of a positive feedback Integrin activation - the importance of a positive feedback

2005-07-07

arxiv.org/abs/q-bio/0507010v2

Biology

Quantitative Biology

Molecular Networks

in press in Bulletin of Mathematical Biology

Scientific paper

10.1007/s11538-005-9049-5

Integrins mediate cell adhesion and are essential receptors for the development and functioning of multicellular organisms. Integrin activation is known to require both ligand and talin binding and to correlate with cluster formation but the activation mechanism and precise roles of these processes are not yet resolved. Here mathematical modeling, with known experimental parameters, is used to show that the binding of a stabilizing factor, such as talin, is alone insufficient to enable ligand-dependent integrin activation for all observed conditions; an additional positive feedback is required.

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