Physics – Biological Physics
Scientific paper
2009-12-11
Physics
Biological Physics
Published in J. Stat. Mech. (2009) P01016 as the paper of the conference "Unsolved Problems of Noise in Physics, Biology and T
Scientific paper
We discuss open problems related to the stochastic modeling of cardiac function. The work is based on an experimental investigation of the dynamics of heart rate variability (HRV) in the absence of respiratory perturbations. We consider first the cardiac control system on short time scales via an analysis of HRV within the framework of a random walk approach. Our experiments show that HRV on timescales of less than a minute takes the form of free diffusion, close to Brownian motion, which can be described as a non-stationary process with stationary increments. Secondly, we consider the inverse problem of modeling the state of the control system so as to reproduce the experimentally observed HRV statistics of. We discuss some simple toy models and identify open problems for the modelling of heart dynamics.
Khovanov I. A.
Khovanova N. A.
McClintock Peter V. E.
Stefanovska Aneta
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