Dynamics of gene expression and the regulatory inference problem

Details Dynamics of gene expression and the regulatory inference problem Dynamics of gene expression and the regulatory inference problem

2007-12-21

arxiv.org/abs/0712.3791v2

Biology

Quantitative Biology

Molecular Networks

revised version to appear in Europhys. Lett., new title

Scientific paper

10.1209/0295-5075/82/28010

From the response to external stimuli to cell division and death, the dynamics of living cells is based on the expression of specific genes at specific times. The decision when to express a gene is implemented by the binding and unbinding of transcription factor molecules to regulatory DNA. Here, we construct stochastic models of gene expression dynamics and test them on experimental time-series data of messenger-RNA concentrations. The models are used to infer biophysical parameters of gene transcription, including the statistics of transcription factor-DNA binding and the target genes controlled by a given transcription factor.

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