Power-law rheology and mechano-sensing in a cytoskeleton model with forced protein unfolding

Details Power-law rheology and mechano-sensing in a cytoskeleton model with forced protein unfolding Power-law rheology and mechano-sensing in a cytoskeleton model with forced protein unfolding

2005-04-07

arxiv.org/abs/physics/0504051v2

Physics

Biological Physics

4 pages, 4 figures, revtex4

Scientific paper

We describe a model of cytoskeletal mechanics based on the force-induced conformational change of protein cross-links in a stressed polymer network. Slow deformation of simulated networks containing cross-links that undergo repeated, serial domain unfolding leads to an unusual state--with many cross-links accumulating near the critical force for further unfolding. Thermal activation of these links gives rise to power-law rheology resembling the previously unexplained mechanical response of living cells. Moreover, we hypothesize that such protein cross-links function as biochemical mechano-sensors of cytoskeletal deformation.

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