Physical Aspects of Cancer Invasion

Details Physical Aspects of Cancer Invasion Physical Aspects of Cancer Invasion

2007-05-30

arxiv.org/abs/0705.4416v1

Physics

Biological Physics

20 pages, 2 figures

Scientific paper

10.1088/1478-3975/4/4/P01

Invasiveness, one of the hallmarks of tumor progression, represents the tumor's ability to expand into the host tissue by means of several complex biochemical and biomechanical processes. Since certain aspects of the problem present a striking resemblance with well known physical mechanisms, such as the mechanical insertion of a solid inclusion in an elastic material specimen [1, 2] or a water drop impinging on a surface [3], we propose here an analogy between these physical processes and a cancer system's invasive branching into the surrounding tissue. Accounting for its solid and viscous properties, we present a unifying concept that the tumor behaves as a granular solid. While our model has been explicitly formulated for multicellular tumor spheroids in vitro, it should also contribute to a better understanding of tumor invasion in vivo.

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