Single-domain protein folding: a multi-faceted problem

Details Single-domain protein folding: a multi-faceted problem Single-domain protein folding: a multi-faceted problem

2008-10-16

arxiv.org/abs/0810.3042v1

FROM PHYSICS TO BIOLOGY: The Interface between Experiment and Computation - BIFI 2006 II International Congress. AIP Conferenc

Physics

Biological Physics

26 pages, AIP Conference Proceedings

Scientific paper

10.1063/1.2345624

We review theoretical approaches, experiments and numerical simulations that have been recently proposed to investigate the folding problem in single-domain proteins. From a theoretical point of view, we emphasize the energy landscape approach. As far as experiments are concerned, we focus on the recent development of single-molecule techniques. In particular, we compare the results obtained with two main techniques: single protein force measurements with optical tweezers and single-molecule fluorescence in studies on the same protein (RNase H). This allows us to point out some controversial issues such as the nature of the denatured and intermediate states and possible folding pathways. After reviewing the various numerical simulation techniques, we show that on-lattice protein-like models can help to understand many controversial issues.

Affiliated with

Also associated with

No associations

Rating

Single-domain protein folding: a multi-faceted problem does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Single-domain protein folding: a multi-faceted problem, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Single-domain protein folding: a multi-faceted problem will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-351662