Brownian Dynamics Simulation of Nucleosome Formation and Disruption under Stretching

Biology – Quantitative Biology – Biomolecules

Scientific paper

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16 pages, 11 figures

Scientific paper

Using a Brownian dynamics simulation, we numerically studied the interaction
of DNA with histone and proposed an octamer-rotation model to describe the
process of nucleosome formation. Nucleosome disruption under stretching was
also simulated. The theoretical curves of extension versus time as well as of
force versus extension are consistent with previous experimental results.

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