Biology – Quantitative Biology – Molecular Networks
Scientific paper
2005-04-02
Biology
Quantitative Biology
Molecular Networks
7 pages, latex
Scientific paper
We propose to model the dynamics of metabolic networks from a systems biology point of view by four dynamical structure elements: potential function, transverse matrix, degradation matrix, and stochastic force. These four elements are balanced to determine the network dynamics, which gives arise to a special stochastic differential equation supplemented by a relationship between the stochastic force and the degradation matrix. Important network behaviors can be obtained from the potential function without explicitly solving for the time-dependent solution. The existence of such a potential function suggests a global optimization principle, and the existence stochastic force corresponds natural to the hierarchical structure in metabolic networks. We provide theoretical evidences to justify our proposal by discussing its connections to others large-scale biochemical systems approaches, such as the network thermodynamics theory, biochemical systems theory, metabolic control analysis, and flux balance analysis. Experimental data displaying stochasticity are also pointed out.
No associations
LandOfFree
Metabolic Network Modelling: Including Stochastic Effects does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Metabolic Network Modelling: Including Stochastic Effects, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Metabolic Network Modelling: Including Stochastic Effects will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-302054