Physics
Scientific paper
Dec 1988
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1988orli...18..389s&link_type=abstract
Origins of Life and Evolution of the Biosphere, Volume 18, Issue 4, pp.389-396
Physics
2
Scientific paper
Simple aliphatic alcohols, deoxynucleosides and nucleosides undergo reaction with formamide yielding formate esters. Formate ester formation was observed to occur slowly at 100°C and more rapidly at 130°C. As expected, formate esters were hydrolyzed to the alcohol and formic acid upon heating in aqueous solution. It was proposed to study the possibility that formate esters are formed initially in amide solvents, followed by displacement of formate by dihydrogen phosphate ion to form monophosphate esters. Experiments are described which demonstrate the formation and hydrolysis of formate esters, as well as their lack of reaction with hydrogen phosphate ion. Formate esters are not intermediates in the phosphorylation of nucleosides in formamide. Their formation has been observed and such an esterification is a side reaction during the phosphorylation of nucleosides in formamide.
Mahone Saralyn M.
Schoffstall Allen M.
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