Speculations on the evolution of the genetic code

Details Speculations on the evolution of the genetic code Speculations on the evolution of the genetic code

Jul 1975

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1975orli....6..423h&link_type=abstract

Origins of Life, Volume 6, Issue 3, pp.423-427

Physics

11

Scientific paper

An evolutionary scheme is postulated in which the bases enter the genetic code in a definite temporal sequence and the correlated amino acids are assigned definite functions in the evolving system. The scheme requires a singlet code (guanine coding for glycine) evolving into a doublet code (guanine-cytosine doublet coding for gly (GG), ala (GC), arg (CG), pro (CC)). The doublet code evolves into a triplet code. Polymerization of nucleotides is thought to have been by block polymerization rather than by a template mechanism. The proteins formed at first were simple structural peptides. No direct nucleotide-amino acid stereo-chemical interaction was required. Rather an adaptor-type indirect mechanism is thought to have been functioning since the origin.

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