Physics
Scientific paper
Aug 1994
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1994sci...265.1221f&link_type=abstract
Science, Volume 265, Issue 5176, pp. 1221-1225
Physics
1
Scientific paper
Transcription of the immunoglobulin μ heavy chain locus is regulated by an intronic enhancer that is flanked on both sides by nuclear matrix attachment regions (MARs). These MARs have now been shown to be essential for transcription of a rearranged μ gene in transgenic B lymphocytes, but they were not required in stably transfected tissue culture cells. Normal rates of transcriptional initiation at a variable region promoter and the formation of an extended deoxyribonuclease I (DNase I)-sensitive chromatin domain were dependent on MARs, although DNase I hypersensitivity at the enhancer was detected in the absence of MARs. Thus, transcriptional activation of the μ gene during normal lymphoid development requires a synergistic collaboration between the enhancer and flanking MARs.
Forrester William C.
Grosschedl Rudolf
Jenuwein Thomas
van Genderen Courtney
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