Cross-linking of Deoxyribonucleic Acid to Protein following Ultra-Violet Irradiation of Different Cells

Details Cross-linking of Deoxyribonucleic Acid to Protein following Ultra-Violet Irradiation of Different Cells Cross-linking of Deoxyribonucleic Acid to Protein following Ultra-Violet Irradiation of Different Cells

Jun 1962

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1962natur.194..882a&link_type=abstract

Nature, Volume 194, Issue 4831, pp. 882-883 (1962).

Physics

Scientific paper

IF deoxyribonucleic acid is exposed to ultra-violet light, especially to the 2537 Å. mercury arc line, a variety of changes occur. In very dilute solution the first physicochemical change is denaturation leading to a fall in viscosity without a change in molecular weight1. With higher doses, main-chain scission occurs and this is markedly enhanced by the presence of oxygen. There is chemical evidence for the formation of a dimer when thymine is irradiated in frozen aqueous solution2 and for cross-linking between molecules when DNA is irradiated in dilute solution3 or as a thin film4. The work reported here has shown that the changes produced in DNA when irradiated as a nucleoprotein inside cells are qualitatively and quantitatively different from those that are produced when pure DNA is treated.

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