Zipf's Law in Gene Expression

Details Zipf's Law in Gene Expression Zipf's Law in Gene Expression

2002-09-30

arxiv.org/abs/physics/0209103v1

Physics

Biological Physics

revtex, 11 pages, 3 figures, submitted to Phys. Rev. Lett

Scientific paper

10.1103/PhysRevLett.90.088102

Using data from gene expression databases on various organisms and tissues, including yeast, nematodes, human normal and cancer tissues, and embryonic stem cells, we found that the abundances of expressed genes exhibit a power-law distribution with an exponent close to -1, i.e., they obey Zipf's law. Furthermore, by simulations of a simple model with an intra-cellular reaction network, we found that Zipf's law of chemical abundance is a universal feature of cells where such a network optimizes the efficiency and faithfulness of self-reproduction. These findings provide novel insights into the nature of the organization of reaction dynamics in living cells.

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