Biology – Quantitative Biology – Molecular Networks
Scientific paper
2005-05-03
Nucleic Acids Research 34 (9) 2812-2819 (2006)
Biology
Quantitative Biology
Molecular Networks
Final, revised version. 13 pages. Please see Nucleic Acids open access article for higher resolution figures
Scientific paper
10.1093/nar/gkl325
The architecture of the network of protein-protein physical interactions in Saccharomyces cerevisiae is exposed through the combination of two complementary theoretical network measures, betweenness centrality and `Q-modularity'. The yeast interactome is characterized by well-defined topological modules connected via a small number of inter-module protein interactions. Should such topological inter-module connections turn out to constitute a form of functional coordination between the modules, we speculate that this coordination is occurring typically in a pair-wise fashion, rather than by way of high-degree hub proteins responsible for coordinating multiple modules. The unique non-hub-centric hierarchical organization of the interactome is not reproduced by gene duplication-and-divergence stochastic growth models that disregard global selective pressures.
Cusick Michael E.
Valente Andre X. C. N.
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