Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery

Details Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery

2010-08-24

arxiv.org/abs/1008.4025v1

Bioinformatics 26, 2042-2050 (2010)

Biology

Quantitative Biology

Molecular Networks

9 pages, 4 figures, 2 tables and a supplementary info with 5 Figures and 13 Tables

Scientific paper

10.1093/bioinformatics/btq310

Motivation: Signaling pathways control a large variety of cellular processes. However, currently, even within the same database signaling pathways are often curated at different levels of detail. This makes comparative and cross-talk analyses difficult. Results: We present SignaLink, a database containing 8 major signaling pathways from Caenorhabditis elegans, Drosophila melanogaster, and humans. Based on 170 review and approx. 800 research articles, we have compiled pathways with semi-automatic searches and uniform, well-documented curation rules. We found that in humans any two of the 8 pathways can cross-talk. We quantified the possible tissue- and cancer-specific activity of cross-talks and found pathway-specific expression profiles. In addition, we identified 327 proteins relevant for drug target discovery. Conclusions: We provide a novel resource for comparative and cross-talk analyses of signaling pathways. The identified multi-pathway and tissue-specific cross-talks contribute to the understanding of the signaling complexity in health and disease and underscore its importance in network-based drug target selection. Availability: http://SignaLink.org

Affiliated with

Also associated with

No associations

Rating

Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-393806