Ubiquity of Log-normal Distributions in Intra-cellular Reaction Dynamic

Details Ubiquity of Log-normal Distributions in Intra-cellular Reaction Dynamic Ubiquity of Log-normal Distributions in Intra-cellular Reaction Dynamic

2005-03-29

arxiv.org/abs/q-bio/0503040v1

BIOPHYSICS, 1 (2005) pp. 25

Biology

Quantitative Biology

Molecular Networks

15 pages, 4 figures. BIOPHYSICS, in press

Scientific paper

The discovery of two fundamental laws concerning cellular dynamics with recursive growth is reported. First, the chemical abundances measured over many cells are found to obey a log-normal distribution and second, the relationship between the average and standard deviation of the abundances is found to be linear. The ubiquity of the laws is explored both theoretically and experimentally. First by means of a model with a catalytic reaction network, the laws are shown to appear near the critical state with efficient self-reproduction. Second by measuring distributions of fluorescent proteins in bacteria cells the ubiquity of log-normal distribution of protein abundances is confirmed. Relevance of these findings to cellular function and biological plasticity is briefly discussed.

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