Two-state folding over a weak free-energy barrier

Details Two-state folding over a weak free-energy barrier Two-state folding over a weak free-energy barrier

2003-12-30

arxiv.org/abs/q-bio/0312046v1

Biophys. J. 85 (2003) 1457-1465

Biology

Quantitative Biology

Biomolecules

22 pages, 5 figures

Scientific paper

10.1016/S0006-3495(03)74578-0

We present a Monte Carlo study of a model protein with 54 amino acids that folds directly to its native three-helix-bundle state without forming any well-defined intermediate state. The free-energy barrier separating the native and unfolded states of this protein is found to be weak, even at the folding temperature. Nevertheless, we find that melting curves to a good approximation can be described in terms of a simple two-state system, and that the relaxation behavior is close to single exponential. The motion along individual reaction coordinates is roughly diffusive on timescales beyond the reconfiguration time for an individual helix. A simple estimate based on diffusion in a square-well potential predicts the relaxation time within a factor of two.

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