Physics – Instrumentation and Detectors
Scientific paper
2010-12-08
Nano Lett., 2011, 11 (5), pp 1941--1945
Physics
Instrumentation and Detectors
12 pages, 3 figures
Scientific paper
10.1021/nl200147x
The fabrication of nanopores in atomically-thin graphene has recently been achieved and translocation of DNA has been demonstrated. Taken together with an earlier proposal to use graphene nanogaps for the purpose of DNA sequencing, this approach can resolve the technical problem of achieving single-base resolution in electronic nucleobase detection. We have theoretically evaluated the performance of a graphene nanogap setup for the purpose of whole-genome sequencing, by employing density functional theory and the non-equilibrium Green's function method to investigate the transverse conductance properties of nucleotides inside the gap. In particular, we determined the electrical tunneling current variation at finite bias due to changes in the nucleotides orientation and lateral position. Although the resulting tunneling current is found to fluctuate over several orders of magnitudes, a distinction between the four DNA bases appears possible, thus ranking the approach promising for rapid whole-genome sequencing applications.
Ahuja Rajeev
Grigoriev Anton
Pathak Biswarup
Prasongkit Jariyanee
Scheicher Ralph H.
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