Transition on the entropic elasticity of DNA induced by intercalating molecules

Details Transition on the entropic elasticity of DNA induced by intercalating molecules Transition on the entropic elasticity of DNA induced by intercalating molecules

2007-04-18

arxiv.org/abs/0704.2346v1

Physics

Biological Physics

This experimental article shows and discuss a transition observed in the persistence length of DNA molecules when studied as a

Scientific paper

10.1063/1.2768945

We use optical tweezers to perform stretching experiments on DNA molecules when interacting with the drugs daunomycin and ethidium bromide, which intercalate the DNA molecule. These experiments are performed in the low-force regime from zero up to 2 pN. Our results show that the persistence length of the DNA-drug complexes increases strongly as the drug concentration increases up to some critical value. Above this critical value, the persistence length decreases abruptly and remains practically constant for larger drug concentrations. The contour length of the molecules increases monotonically and saturates as drugs concentration increases. Measured in- tercalants critical concentrations for the persistence length transition coincide with reported values for the helix-coil transition of DNA-drug complexes, obtained from sedimentation experiments.

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