Transcriptional bursts: a unified model of machines and mechanisms

Details Transcriptional bursts: a unified model of machines and mechanisms Transcriptional bursts: a unified model of machines and mechanisms

2008-04-08

arxiv.org/abs/0804.1227v2

Physics

Biological Physics

Accepted for publication in Europhysics letters

Scientific paper

10.1209/0295-5075/84/68004

{\it Transcription} is the process whereby RNA molecules are polymerized by molecular machines, called RNA polymerase (RNAP), using the corresponding DNA as the template. Recent {\it in-vivo} experiments with single cells have established that transcription takes place in "bursts" or "pulses". In this letter we present a model that captures not only the mechano-chemistry of individual RNAPs and their steric interactions but also the switching of the gene between the ON and OFF states. This model accounts for the statistical properties of the transcriptional bursts. It also shows how the quantitative features of the distributions of these bursts can be tuned by controlling the appropriate steps of operation of the RNAP machines.

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