Towards Biosensing Strategies Based on Biochemical Logic Systems

Details Towards Biosensing Strategies Based on Biochemical Logic Systems Towards Biosensing Strategies Based on Biochemical Logic Systems

2009-09-08

arxiv.org/abs/0909.1583v1

Proc. Conf. ICQNM 2010, edited by V. Ovchinnikov and V. Privman (IEEE Comp. Soc. Conf. Publ. Serv., Los Alamitos, California,

Physics

Biological Physics

Scientific paper

10.1109/ICQNM.2010.8

Recent advances in biochemical computing, i.e., information processing with cascades of primarily enzymatic reactions realizing computing gates, such as AND, OR, etc., as well as progress in networking these gates and coupling of the resulting systems to smart/responsive electrodes for output readout, have opened new biosensing opportunities. Here we survey existing enabling research results, as well as ideas and research avenues for future development of a new paradigm of digitally operating biosensors logically processing multiple biochemical signals through Boolean logic networks composed of biomolecular reactions, yielding the final output signals as YES/NO responses. Such systems can lead to high-fidelity biosensing compared to common single or parallel sensing devices.

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