Thermodynamics of G.A mispairs in DNA: continuum electrostatic model

Details Thermodynamics of G.A mispairs in DNA: continuum electrostatic model Thermodynamics of G.A mispairs in DNA: continuum electrostatic model

2008-07-10

arxiv.org/abs/0807.1712v1

J. Chem. Phys. 130, 015101 (2009)

Physics

Biological Physics

Scientific paper

10.1063/1.3050107

An analysis of the stability of a duplex containing G.A mispairs or G.A/A.G tandem during DNA melting has revealed that duplex stability depends on both DNA sequences and on the conformations of the G.A mispairs. The thermodynamics of single pair opening for G(anti).A(syn) and G(anti).A(anti) conformations adopted by G.A mispairs is found to strongly correlate with that of the canonical base pairs, while for sheared conformation a significant difference is observed.

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