Thermal unfolding of proteins

Details Thermal unfolding of proteins Thermal unfolding of proteins

2006-01-30

arxiv.org/abs/q-bio/0601049v1

J. Chem. Phys. 123, 194908 (2005)

Biology

Quantitative Biology

Biomolecules

3 figures, a text in latex

Scientific paper

10.1063/1.2121668

Thermal unfolding of proteins is compared to folding and mechanical stretching in a simple topology-based dynamical model. We define the unfolding time and demonstrate its low-temperature divergence. Below a characteristic temperature, contacts break at separate time scales and unfolding proceeds approximately in a way reverse to folding. Features in these scenarios agree with experiments and atomic simulations on titin.

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