Theory for stability and regulation of epigenetic landscapes

Details Theory for stability and regulation of epigenetic landscapes Theory for stability and regulation of epigenetic landscapes

2010-02-08

arxiv.org/abs/1002.1600v2

Phys. Biol. 7, 026010 (2010)

Biology

Quantitative Biology

Molecular Networks

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Scientific paper

Cells can often choose among several stably heritable phenotypes. Examples are the expression of genes in eukaryotic cells where long chromosomal regions can adopt persistent and heritable silenced or active states, that may be associated with positive feedback in dynamic modification of nucleosomes. We generalize this mechanism in terms of bistability associated with valleys in an epigenetic landscape. A transfer matrix method was used to rigorously follow the system through the disruptive process of cell division. This combined treatment of noisy dynamics both between and during cell division provides an efficient way to calculate the stability of alternative states in a broad range of epigenetic systems.

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