The Worm-Like Chain Theory And Bending Of Short DNA

Details The Worm-Like Chain Theory And Bending Of Short DNA The Worm-Like Chain Theory And Bending Of Short DNA

2007-04-30

arxiv.org/abs/0704.3948v1

Phys. Rev. Lett. 98, 218102, 2007.

Biology

Quantitative Biology

Biomolecules

4 pages, 3 figures, to appear in PRL

Scientific paper

10.1103/PhysRevLett.98.218102

The probability distributions for bending angles in double helical DNA obtained in all-atom molecular dynamics simulations are compared with theoretical predictions. The computed distributions remarkably agree with the worm-like chain theory for double helices of one helical turn and longer, and qualitatively differ from predictions of the semi-elastic chain model. The computed data exhibit only small anomalies in the apparent flexibility of short DNA and cannot account for the recently reported AFM data (Wiggins et al, Nature nanotechnology 1, 137 (2006)). It is possible that the current atomistic DNA models miss some essential mechanisms of DNA bending on intermediate length scales. Analysis of bent DNA structures reveals, however, that the bending motion is structurally heterogeneous and directionally anisotropic on the intermediate length scales where the experimental anomalies were detected. These effects are essential for interpretation of the experimental data and they also can be responsible for the apparent discrepancy.

Affiliated with

Also associated with

No associations

Rating

The Worm-Like Chain Theory And Bending Of Short DNA does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with The Worm-Like Chain Theory And Bending Of Short DNA, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and The Worm-Like Chain Theory And Bending Of Short DNA will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-415478