The Topology of Pseudoknotted Homopolymers

Details The Topology of Pseudoknotted Homopolymers The Topology of Pseudoknotted Homopolymers

2005-08-29

arxiv.org/abs/q-bio/0508042v2

Biology

Quantitative Biology

Biomolecules

RevTeX 4 pages, 6 figures, minor typos fixed

Scientific paper

10.1103/PhysRevE.73.031902

We consider the folding of a self-avoiding homopolymer on a lattice, with saturating hydrogen bond interactions. Our goal is to numerically evaluate the statistical distribution of the topological genus of pseudoknotted configurations. The genus has been recently proposed for classifying pseudoknots (and their topological complexity) in the context of RNA folding. We compare our results on the distribution of the genus of pseudoknots, with the theoretical predictions of an existing combinatorial model for an infinitely flexible and stretchable homopolymer. We thus obtain that steric and geometric constraints considerably limit the topological complexity of pseudoknotted configurations, as it occurs for instance in real RNA molecules. We also analyze the scaling properties at large homopolymer length, and the genus distributions above and below the critical temperature between the swollen phase and the compact-globule phase, both in two and three dimensions.

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