The Stability of Boolean Networks with Generalized Canalizing Rules

Details The Stability of Boolean Networks with Generalized Canalizing Rules The Stability of Boolean Networks with Generalized Canalizing Rules

2009-10-03

arxiv.org/abs/0910.0509v3

Biology

Quantitative Biology

Molecular Networks

20 pages, 3 figures

Scientific paper

Boolean networks are discrete dynamical systems in which the state (zero or one) of each node is updated at each time t to a state determined by the states at time t-1 of those nodes that have links to it. When these systems are used to model genetic control, the case of 'canalizing' update rules is of particular interest. A canalizing rule is one for which a node state at time $t$ is determined by the state at time t-1 of a single one of its inputs when that inputting node is in its canalizing state. Previous work on the order/disorder transition in Boolean networks considered complex, non-random network topology. In the current paper we extend this previous work to account for canalizing behavior.

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