The Scaling Behaviour of Stochastic Minimization Algorithms in a Perfect Funnel Landscape

Physics – Biological Physics

Scientific paper

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accepted for publication in Phys. Rev. E, January 1999

Scientific paper

10.1103/PhysRevE.59.938

We determined scaling laws for the numerical effort to find the optimal configurations of a simple model potential energy surface (PES) with a perfect funnel structure that reflects key characteristics of the protein interactions. Generalized Monte-Carlo methods(MCM, STUN) avoid an enumerative search of the PES and thus provide a natural resolution of the Levinthal paradox. We find that the computational effort grows with approximately the eighth power of the system size for MCM and STUN, while a genetic algorithm was found to scale exponentially. The scaling behaviour of a derived lattice model is also rationalized.

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