Biology – Quantitative Biology – Biomolecules
Scientific paper
2008-07-14
Biology
Quantitative Biology
Biomolecules
17 pages, 1 figure, 1 table
Scientific paper
The interaction cutoff contribution to the ruggedness of protein-protein energy landscape (the artificial ruggedness) is studied in terms of relative energy fluctuations for 1/r^n potentials based on a simplistic model of a protein complex. Contradicting the principle of minimal frustration, the artificial ruggedness exists for short cutoffs and gradually disappears with the cutoff increase. The critical values of the cutoff were calculated for each of eleven popular power-type potentials with n=0-9, 12 and for two thresholds of 5% and 10%. The artificial ruggedness decreases to tolerable thresholds for cutoffs longer than the critical ones. The results showed that for both thresholds the critical cutoff is a non-monotonic function of the potential power n. The functions reach the maximum at n=3-4 and then decrease with the increase of the potential power. The difference between two cutoffs for 5% and 10% artificial ruggedness becomes negligible for potentials decreasing faster than 1/r^12. The results suggest that cutoffs longer than critical ones can be recommended for protein-protein potentials.
Ruvinsky Anatoly M.
Vakser Ilya A.
No associations
LandOfFree
The ruggedness of protein-protein energy landscape and the cutoff for 1/r^n potentials does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with The ruggedness of protein-protein energy landscape and the cutoff for 1/r^n potentials, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and The ruggedness of protein-protein energy landscape and the cutoff for 1/r^n potentials will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-443731