The relevance of neck linker docking in the motility of kinesin

Details The relevance of neck linker docking in the motility of kinesin The relevance of neck linker docking in the motility of kinesin

2008-04-21

arxiv.org/abs/0804.3275v1

BioSystems 93, 29-33 (2008)

Physics

Biological Physics

Accepted for publication in BioSystems as part of the proceedings of BIOCOMP 2007

Scientific paper

10.1016/j.biosystems.2008.04.006

Conventional kinesin is a motor protein, which is able to walk along a microtubule processively. The exact mechanism of the stepping motion and force generation of kinesin is still far from clear. In this paper we argue that neck linker docking is a crucial element of this mechanism, without which the experimentally observed dwell times of the steps could not be explained under a wide range of loading forces. We also show that the experimental data impose very strict constraints on the lengths of both the neck linker and its docking section, which are compatible with the known structure of kinesin.

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