The relation of morphology and affinity maturation in germinal centers

Details The relation of morphology and affinity maturation in germinal centers The relation of morphology and affinity maturation in germinal centers

2002-03-14

arxiv.org/abs/physics/0203045v2

Physics

Biological Physics

10 pages, 2 figures, 25 references

Scientific paper

The specific morphology of germinal centers is analyzed in the context of the optimization of the humoral immune response. The relevance of dark and light zones for the affinity maturation process is investigated in the framework of a theoretical model for the germinal center reaction. Especially, it is shown that an intermediate appearance of dark zones in germinal center reactions is advantageous for the process of antibody optimization. Methodological aspects are discussed.

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