Physics – Biological Physics
Scientific paper
2008-12-02
Physics
Biological Physics
6 pages, 1 figure
Scientific paper
Under externally applied electric fields, lipid membranes tend to permeate and change their electrical resistance by the combined processes of pore creation and pore evolution (expansion or contraction). This study is focused on the pore creation process, represented by an empirical expression currently used in the electroporation (EP) models, for which an alternative theoretically based expression was provided. The choice of this expression was motivated by the role the DLVO's (disjoining) pressures may play in the process of EP. The electrostatic energy effects on each sides of a lipid membrane were evaluated in terms of the electrostatic component of the disjoining pressure. Thus the pore creation energy considerations in the current EP models, associated with the necessity of an idealized non conducting circular pre-pore were avoided. As a result, a new expression for the onset of the electroporation was proposed. It was found that this new theoretically determined expression is in good agreement with the one estimated from an experiment that specifically targeted the pore nucleation by eliminating the pore evolution process. Furthermore, the proposed expression is dependent on the electrolyte and the lipid properties and should provide better predictability than the currently used pore creation EP model, which is only temperature dependent.
No associations
LandOfFree
The Electrostatic Component of the Disjoining Pressure and the Pore Creation Rate in Electroporation Models and Theory does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with The Electrostatic Component of the Disjoining Pressure and the Pore Creation Rate in Electroporation Models and Theory, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and The Electrostatic Component of the Disjoining Pressure and the Pore Creation Rate in Electroporation Models and Theory will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-719022