Physics
Scientific paper
Aug 1999
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1999oleb...29..391w&link_type=abstract
Origins of Life and Evolution of the Biosphere, v. 29, Issue 4, p. 391-404 (1999).
Physics
1
Scientific paper
Viomycin is an RNA-binding peptide antibiotic which inhibits prokaryotic protein synthesis and group I intron self-splicing. This antibiotic enhances the activity of the ribozyme derived from the Neurospora crassa VS RNA, and at sub-inhibitory concentrations it induces the formation of group I intron oligomers. Here, we address the question whether viomycin exerts specificity in the promotion of RNA-RNA interactions. In an in vitro selection experiment we tested the ability of viomycin to specifically select molecules out of an RNA pool. Group I intron RNA was incubated with a pool of random sequence RNA, or with a pool of RNA molecules which had previously been enriched for viomycin-binding RNAs. Viomycin was added in order to select viomycin-binding RNAs and to guide their interaction with the intron RNA resulting in recombinant molecules. Viomycin was indeed capable of specifically selecting RNA molecules which contain viomycin-binding sites promoting recombination. These results suggest that small peptides are able to play the role of selector molecules in a putative `RNA World' launching the co-evolution of RNA and proteins into an `RNA-protein World'.
Clodi Elisabeth
Schroeder Renée
Wallis Mary G.
Wank Herbert
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