Physics
Scientific paper
Aug 2003
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2003esasp.530..249c&link_type=abstract
In: 16th ESA Symposium on European Rocket and Balloon Programmes and Related Research, 2 - 5 June 2003, Sankt Gallen, Switzerlan
Physics
Space Flight: Life Science
Scientific paper
Within the frame of a project supported by the Microgravity Application Program of ESA we have developed a module for the growth of cartilage tissue starting from primary chondrocytes. The module is based on the scaffold-free chamber "Denovo" of Centerpulse. The long-term goal of the project is the development of a modular bioreactor for tissue engineering on the International Space Station. The two objectives of the experiment on MASER 9 were: first, to test the module and its service unit, second, to investigate whether short exposure to microgravity may after the structure of the cytoskeleton and genetic expression of 10 selected genes. Post-flight analyses showed that the apparatus worked nominally. No changes were detected in the cytoskeleton. The genetic expression of biglycan was slightly depressed at 0g.
Berardi-Vilei Simona
Bruckner Peter
Cogoli Augusto
Conza Nadine
Dreier Rita
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