Nonlinear Sciences – Chaotic Dynamics
Scientific paper
2004-06-21
Nonlinear Sciences
Chaotic Dynamics
6 pages, 2 figures, to appear in Proc. Int. Conf. Math. Biol. 2004 (IIT Kanpur, India)
Scientific paper
Formation of feedback loops of excitation waves (reentrant circuit) around non-conducting ventricular scar tissue is a common cause of lethal cardiac arrhythmias, such as ventricular tachycardia. This is typically treated by rapid stimulation from an implantable device (ICD). However, the mechanisms of reentry termination success and, more importantly, failure, are poorly understood. To study such mechanisms, we simulated pacing of anatomical reentry in an ionic model of cardiac tissue, having significant restitution and dispersion properties. Our results show that rapid pacing causes inhomogeneous conduction in the reentrant circuit, leading to successful pacing termination of tachycardia. The study suggests that more effective pacing algorithms can be designed by taking into account the role of such dynamical inhomogeneities.
Breuer Johannes
Sinha Sitabhra
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