Synthesis of Nucleoside N-Phosphoamino Acids and Peptide Formation

Details Synthesis of Nucleoside N-Phosphoamino Acids and Peptide Formation Synthesis of Nucleoside N-Phosphoamino Acids and Peptide Formation

Feb 2005

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2005oleb...35...11l&link_type=abstract

Origins of Life and Evolution of Biospheres, Volume 35, Issue 1, pp.11-17

Physics

Amino Acid, Nucleoside, Phosphonate, Peptide Formation, Prebiotic Synthesis

Scientific paper

Nucleoside N-phosphoamino acids were synthesized through Atherton-Todd reaction of nucleoside H-phosphonate with amino acids, and their structures were confirmed by NMR and ESI-MS. After nucleoside N-phosphoamino acid was incubated in anhydrous methanol at 40 °C for 72 h, di- to tetra-peptide derivatives were detected by ESI-MS, and their structures were further identified by multistage mass spectrometry. These and previously published studies in aqueous solution suggest that nucleoside N-phosphoamino acids could have been prebiotic precursors of oligopeptides.

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