Biology – Quantitative Biology – Molecular Networks
Scientific paper
2009-04-03
Phys. Rev. E 79, 041903 (2009)
Biology
Quantitative Biology
Molecular Networks
30 pages, 8 figures
Scientific paper
10.1103/PhysRevE.79.041903
The effect of signal integration through cis-regulatory modules (CRMs) on synchronization and clustering of populations of two-component genetic oscillators coupled by quorum sensing is in detail investigated. We find that the CRMs play an important role in achieving synchronization and clustering. For this, we investigate 6 possible cis-regulatory input functions (CRIFs) with AND, OR, ANDN, ORN, XOR, and EQU types of responses in two possible kinds of cell-to-cell communications: activator-regulated communication (i.e., the autoinducer regulates the activator) and repressor-regulated communication (i.e., the autoinducer regulates the repressor). Both theoretical analysis and numerical simulation show that different CRMs drive fundamentally different cellular patterns, such as complete synchronization, various cluster-balanced states and several cluster-nonbalanced states.
Yuan Zhanjiang
Zhang Jiajun
Zhou Tianshou
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