Stress relaxation microscopy (STREM): Imaging mechanical force decay in cells

Details Stress relaxation microscopy (STREM): Imaging mechanical force decay in cells Stress relaxation microscopy (STREM): Imaging mechanical force decay in cells

2009-04-17

arxiv.org/abs/0904.2704v1

Physics

Biological Physics

13 pages, 4 figures

Scientific paper

We have developed a novel scanning probe-based methodology to study cell biomechanics. The time dependence of the force exerted by the cell surface on a scanning probe at constant local deformation has been used to extract local relaxational responses. The generalized Maxwell viscoelastic model that accounts for multi relaxations fully describes the mechanical behaviour of the cell surface that exhibits a bimodal relaxation. Within the range of tested forces (0.1-4 nN) a slow and a fast relaxation with characteristic times of 0.1 and 1s have been detected and assigned to rearrangements in the cell membrane and cytoskeleton cortex, respectively. Relaxation time mapping allows to simultaneously detect non-uniformities in membrane and cytoskeletal mechanical behaviour and can be used as both identifying and diagnosing tools for cell type and cell disease.

Affiliated with

Also associated with

No associations

Rating

Stress relaxation microscopy (STREM): Imaging mechanical force decay in cells does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Stress relaxation microscopy (STREM): Imaging mechanical force decay in cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stress relaxation microscopy (STREM): Imaging mechanical force decay in cells will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-141435