Stress Clamp Experiments on Multicellular Tumor Spheroids

Details Stress Clamp Experiments on Multicellular Tumor Spheroids Stress Clamp Experiments on Multicellular Tumor Spheroids

2011-11-24

arxiv.org/abs/1111.5814v1

Phys. Rev. Lett. 107, 188102 (2011)

Physics

Biological Physics

5 pages, 4 figures

Scientific paper

10.1103/PhysRevLett.107.188102

The precise role of the microenvironment on tumor growth is poorly understood. Whereas the tumor is in constant competition with the surrounding tissue, little is known about the mechanics of this interaction. Using a novel experimental procedure, we study quantitatively the effect of an applied mechanical stress on the long-term growth of a spheroid cell aggregate. We observe that a stress of 10 kPa is sufficient to drastically reduce growth by inhibition of cell proliferation mainly in the core of the spheroid. We compare the results to a simple numerical model developed to describe the role of mechanics in cancer progression.

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