Stochastic modeling of p53-regulated apoptosis upon radiation damage

Details Stochastic modeling of p53-regulated apoptosis upon radiation damage Stochastic modeling of p53-regulated apoptosis upon radiation damage

2011-09-04

arxiv.org/abs/1109.0743v1

Physics

Biological Physics

Scientific paper

We develop and study the evolution of a model of radiation induced apoptosis in cells using stochastic simulations, and identified key protein targets for effective mitigation of radiation damage. We identified several key proteins associated with cellular apoptosis using an extensive literature survey. In particular, we focus on the p53 transcription dependent and p53 transcription independent pathways for mitochondrial apoptosis. Our model reproduces known p53 oscillations following radiation damage. The key, experimentally testable hypotheses that we generate are - inhibition of PUMA is an effective strategy for mitigation of radiation damage if the treatment is administered immediately, at later stages following radiation damage, inhibition of tBid is more effective.

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