Statistical properties of metastable intermediates in DNA unzipping

Details Statistical properties of metastable intermediates in DNA unzipping Statistical properties of metastable intermediates in DNA unzipping

2010-10-06

arxiv.org/abs/1010.1169v1

Phys. Rev. Lett. 103, 248106 (2009)

Physics

Biological Physics

Main text: 4 pages, 3 figures. Supplementary Information: 18 pages, 15 figures

Scientific paper

10.1103/PhysRevLett.103.248106

We unzip DNA molecules using optical tweezers and determine the sizes of the cooperatively unzipping and zipping regions separating consecutive metastable intermediates along the unzipping pathway. Sizes are found to be distributed following a power law, ranging from one base pair up to more than a hundred base pairs. We ?nd that a large fraction of unzipping regions smaller than 10 bp are seldom detected because of the high compliance of the released single stranded DNA. We show how the compliance of a single nucleotide sets a limit value around 0.1 N/m for the sti?ness of any local force probe aiming to discriminate one base pair at a time in DNA unzipping experiments.

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