Specific protein-protein binding in many-component mixtures of proteins

Details Specific protein-protein binding in many-component mixtures of proteins Specific protein-protein binding in many-component mixtures of proteins

2003-12-19

arxiv.org/abs/q-bio/0312033v2

Physical Biology v1, 53 (2004)

Biology

Quantitative Biology

Biomolecules

13 pages, 3 figures (changes for v2 mainly notational - to be more in line with notation in information theory literature)

Scientific paper

10.1088/1478-3967/1/2/001

Proteins must bind to specific other proteins in vivo in order to function. The proteins must bind only to one or a few other proteins of the of order a thousand proteins typically present in vivo. Using a simple model of a protein, specific binding in many component mixtures is studied. It is found to be a demanding function in the sense that it demands that the binding sites of the proteins be encoded by long sequences of bits, and the requirement for specific binding then strongly constrains these sequences. This is quantified by the capacity of proteins of a given size (sequence length), which is the maximum number of specific-binding interactions possible in a mixture. This calculation of the maximum number possible is in the same spirit as the work of Shannon and others on the maximum rate of communication through noisy channels.

Affiliated with

Also associated with

No associations

Rating

Specific protein-protein binding in many-component mixtures of proteins does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Specific protein-protein binding in many-component mixtures of proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Specific protein-protein binding in many-component mixtures of proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-199150