Some protein interaction data do not exhibit power law statistics

Details Some protein interaction data do not exhibit power law statistics Some protein interaction data do not exhibit power law statistics

2005-06-27

arxiv.org/abs/q-bio/0506038v1

FEBS Letters 579 (2005) 514--5144

Biology

Quantitative Biology

Molecular Networks

4 pages, 2 figures

Scientific paper

10.1016/j.febslet.2005.08.024

It has been claimed that protein-protein interaction (PPI) networks are scale-free based on the observation that the node degree sequence follows a power law. Here we argue that these claims are likely to be based on erroneous statistical analysis. Typically, the supporting data are presented using frequency-degree plots. We show that such plots can be misleading, and should correctly be replaced by rank-degree plots. We provide two PPI network examples in which the frequency-degree plots appear linear on a log-log scale, but the rank-degree plots demonstrate that the node degree sequence is far from a power law. We conclude that at least these PPI networks are not scale-free.

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