Solvation model dependency of helix-coil transition in polyalanine

Physics – Biological Physics

Scientific paper

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to appear in Biophysical Journal

Scientific paper

10.1016/S0006-3495(02)75668-3

Helix-coil transitions in poly-alanine molecules of length 10 are studied by multicanonical Monte Carlo simulations. The solvation effects are included by either a distance-dependent dielectric permittivity or by a term that is proportional to the solvent-accessible surface area of the peptide. We found a strong dependence of the characteristics of the helix-coil transition from the details of the solvation model.

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